SAAM II: Simulation, Analysis, and Modeling Software
for tracer and pharmacokinetic studies
Kinetic analysis and integrated systems modeling
have contributed substantially to our understanding of
the physiology and pathophysiology of metabolic systems
and the distribution and clearance of drugs in humans and animals.
In recent years, many researchers have become aware of
the usefulness of these techniques in the experimental design.
With this has come the recognition that the discipline of
kinetic analysis requires its own expertise.
The expertise can impact experimental design in many ways,
from the collaborative and service activities in which individuals
interact in formal ways to the development of software tools
to aid in kinetic analysis.
The purpose of this report is to describe
one such software tool,
Simulation, Analysis, and Modeling Software II (SAAM II).
In the first part,
we describe in general how the user can take advantage
of the capabilities of the software system,
and in the second part, we give three specific examples
using multicompartmental models found in
lipoprotein (apolipoprotein B [apoB] kinetics)
and diabetes (glucose minimal model) research.